By Ashok Garg
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Trans Am Ophthalmol Soc 2006;104:212-20. 5. Clair-Florent M, Schmitt-Bernard C, Lesage C, Arnaud B. Keratectasia induced by laser in situ keratomileusis in keratoconus. J Refract Surg 2000;16:368-70. 6. Argento C, Cosentino MJ, Tytiun A, et al. Corneal ectasia after laser in situ keratomileusis. J Cataract Refract Surg 2001;27:1440–48. 7. Lafond G, Bazin R, Lajoie C. Bilateral severe keratoconus after laser in situ keratomileusis in a patient with forme fruste keratoconus. J Cataract Refract Surg 2001;27:1115– 18.
Repopulation of this area takes up to 6 months. As long as the cornea treated has a minimum thickness of 400 mm the corneal endothelium will not experience damage, nor will deeper structures such as lens and retina. To prevent damage to the endothelium, the lens or the retina, safe clinical application of X-linking must respect the following criteria: 1. For diffusion of riboflavin throughout the corneal stroma, the epithelium should be removed. 2. Riboflavin solution should be applied for at least 5 minutes allowing riboflavin to permeate through the cornea before the UV irradiation (during the UV exposure, the riboflavin serves as both a photosensitizer and a UV blocker) 3.
Ophthalmologica 2008;222:334-37. 19 MASTERING CORNEAL COLLAGEN CROSS-LINKING TECHNIQUES 12. Condon PI. Will Keratectasia be a major complication for LASIK in the long-term? J Cataract Refract Surg 2006;32:2124-32. 13. Binder PS. Ectasia after laser in situ keratomileusis. J Cataract Refract Surg 2003;29:2419-29. 14. Faraj HG, Gatinel D, Chastang PJ, Hoang-Xuan T. Corneal ectasia after LASIK. J Cataract Refract Surg 2003;29:220. 15. Randleman J, Woodward M, Lynn M, Stulting RD. Risk assessment for ectasia after corneal refractive surgery.