Download Experimental Approaches to Diabetic Retinopathy (Frontiers by H.-P. Hammes, M. Porta, F.M. Matschinsky PDF

By H.-P. Hammes, M. Porta, F.M. Matschinsky

This quantity units the level for scientific specialists operating with diabetic sufferers in addition to for researchers by means of describing the scientific displays of retinopathy and their anatomical and practical correlates. It experiences presently to be had experimental versions in animals. The effect of retinal pericytes, neuroglia and, in particular, Mueller cells are mentioned intimately. the amount addresses quite a few present clinical discussions approximately mechanisms of wear and tear comparable to progress elements and the VEGF/PEDF stability within the diabetic eye, the ocular renin-angiotensin method, and leukocyte interactions with the microvasculature between others. Stem and progenitor cells within the retina are mentioned as strength instructions for destiny research. the ultimate chapters go back to rising medical facets, together with present techniques to retinopathy as a predictor of cardiovascular hazard and the way wisdom might be translated from bench to bedside. Bridging a widening hole in scientific examine among simple scientists, who could lose sight of the scientific displays, and scientific researchers, who may well develop ignorant of the boundaries of experimental versions, this quantity serves as a reference platform for endocrinologists, diabetologists, ophthalmologists, in addition to for scientists occupied with medical and simple examine in diabetic retinopathy and different vascular problems of diabetes.

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Extra resources for Experimental Approaches to Diabetic Retinopathy (Frontiers in Diabetes Vol 20)

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J Cell Biol 1998;141:199– 208. 47 Itoh M, Morita K, Tsukita S: Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem 1999;274:5981–5986. 48 Gonzalez-Mariscal L, Betanzos A, Avila-Flores A: MAGUK proteins: structure and role in the tight junction. Semin Cell Dev Biol 2000;11:315–324. Poulaki 49 Schmidt A, Utepbergenov DI, Mueller SL, Beyermann M, Schneider-Mergener J, Krause G, Blasig IE: Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1:potential mechanism of tight junction regulation.

32 Antonetti DA, Wolpert EB, DeMaio L, Harhaj NS, Scaduto RC Jr: Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin. J Neurochem 2002;80:667–677. 33 Chieh JJ, Roth DB, Liu M, Belmont J, Nelson M, Regillo C, Martidis A: Intravitreal triamcinolone acetonide for diabetic macular edema. Retina 2005;25:828–834. 34 Schulzke JD, Gitter AH, Mankertz J, Spiegel S, Seidler U, Amasheh S, Saitou M, Tsukita S, Fromm M: Epithelial transport and barrier function in occludin-deficient mice.

Semin Cell Dev Biol 2000;11:315–324. Poulaki 49 Schmidt A, Utepbergenov DI, Mueller SL, Beyermann M, Schneider-Mergener J, Krause G, Blasig IE: Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1:potential mechanism of tight junction regulation.

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