By Juan Manuel Mejía-Aranguré
Childhood acute leukemias are one of many major reasons of demise in young ones elderly 1 to fourteen years in a few international locations; and regrettably, we've got been not able to avoid it. definitely, a very good parcel of it truly is as a result terrible figuring out approximately its etiology. This publication goals to explain an important theories and speculation concerning youth acute leukemia. Written via the main impressive researchers within the box, this booklet intends to give a contribution to a better realizing of the etiology of this ailment. It is going past the straightforward and customary research of hazard components, which infrequently permits us to attract convinced conclusions. by means of addressing the etiology of the sickness, discussing from molecular biology till epidemiology and medical manifestations, this e-book will advisor current and destiny techniques, contributing for a greater scientific administration of leukemia in kids. the data relating to etiology is an important step for a greater assessment, prevention and remedy of a ailment. hence, this booklet eventually intends to supply such wisdom, permitting physicians and practitioners to a greater deal with of formative years acute leukemias.
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So far, it has only been found in acute megakaryocytic leukemia, specifically in children younger than 3 years, and is not associated with DS (Martinez-Climent et al. 1995). The t(1;22) involves the RBM15 and MKL1 genes. The fusion protein may modulate chromatin organization, HOX differentiation pathways, or extracellular signaling pathways (Ma et al. 2001). In 20–25 % of childhood AML cases, no chromosomal abnormalities are visible by conventional karyotyping and are referred to as cytogenetically normal AML.
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