By P.B. Bradley, B.N. Dhawan
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And Ryall, R. W. (1966). 'An investigation of catecholamine receptors of spinal interneurones', Int. ]. , 5, 429-434 Biscoe, T. , Duggan, A. W. and Lodge, D. (1973). 'Actions of pancuronium on Renshaw cells of the rat spinal cord', Comp. gen. , 4, 179-181 Bloom, F. E. (1974). , 14, 1819-1834 Bloom, F. , Nelson, C. N. and Siggins, C. R. (1973). 'Studies in the function of central noradrenergic neurons'. Neurosci. , 5, 53-72 Bloom, F. , Siggins, G. , Barker,J. L. and Nicoll, R. A. (1972). 'Effects of serotonin on central neurons: microiontophoretic administration', Fedn Proc.
CONCLUSION The use of agents which interfere with the synthesis, release, postsynaptic action and inactivation of central transmitters for studying central synapses has both advantages and disadvantages when compared with the systemic administration of drugs, and the type of antagonism and particularly the degree of specificity demonstrated, may be difficult to evaluate. For practical purposes, specificity can be considered to be a measure of the degree of certainty with which the suppression of a process associated with synaptic transmission can be accepted as indicating the participation of one compound, and not another, as the transmitter.
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